Efficacy of fosfomycin trometamol and cefuroxime axetil in the treatment of UTI during pregnancy: A comparative study

Abstract

Objective: To compare the efficacy of fosfomycin trometamol and cefuroxime axetil in the treatment of urinary tract infections during pregnancy. Methods: Prospective clinical study was conducted among pregnant women who were followed as part of routine prenatal care at Government Hospital Sarwal, Jammu, India with complaints of lower UTI were assessed. 60 patients were enrolled, divided into 2 equal groups for treatment with single-dose fosfomycin trometamol and 5-day courses of cefuroxime axetil. Follow-up was carried out after 5 weeks. Results: The treatment groups did not differ significantly in terms of demographics, clinical compliance rate and adverse effects. But the patients who were taking 5-day courses of cefuroxime axetil showed statistically significant higher cure rate as well as lower recurrence rate as compared to fosfomycin trometamol group. Conclusion: Treatment with a single dose of fosfomycin trometamol and 5-day courses of cefuroxime axetil were found similar in terms of compliance rate and adverse effects but effectiveness in curing the UTI significantly higher higher among patients who were taking 5-day courses of cefuroxime axetil therapy.