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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Clinical Infectious Diseases · 2020 · Vol. 71(9) · pp. 2428–2446

Jasper Fuk‐Woo Chan(University of Hong Kong - Shenzhen Hospital)Jinxia Zhang(University of Hong Kong)Shuofeng Yuan(University of Hong Kong)Vincent Kwok‐Man Poon(University of Hong Kong)Chris Chung-Sing Chan(University of Hong Kong)Andrew Chak-Yiu Lee(University of Hong Kong)Wan-Mui Chan(University of Hong Kong)Zhimeng Fan(University of Hong Kong)Hoi-Wah Tsoi(University of Hong Kong)Lei Wen(University of Hong Kong)Ronghui Liang(University of Hong Kong)Jianli Cao(University of Hong Kong)Yanxia Chen(University of Hong Kong)Kaiming Tang(University of Hong Kong)Cuiting Luo(University of Hong Kong)Jian‐Piao Cai(University of Hong Kong)Kin‐Hang Kok(University of Hong Kong)Hin Chu(University of Hong Kong)Kwok‐Hung Chan(University of Hong Kong)Siddharth Sridhar(University of Hong Kong)Zhiwei Chen(University of Hong Kong)Honglin Chen(University of Hong Kong)Kelvin Kai‐Wang To(University of Hong Kong)Kwok‐Yung Yuen✉(University of Hong Kong)

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Abstract

Besides satisfying Koch's postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2.

SARS-CoV-2 and COVID-19 Research COVID-19 Clinical Research Studies Long-Term Effects of COVID-19HamsterMesocricetusVirologyViral loadVirusImmunologyMedicineTiterAntibodyNeutralizing antibody