Comparative study of haemodynamic stability of Propofol versus Etomidate during Endoscopic Retrograde Cholangio pancreatography

Abstract

Background: Endoscopic procedures like ERCP are performed with patient under moderate sedation. Recently sedation with etomidate and propofol was compared for colonoscopy. Etomidate–Remifentanil administration for sedation and analgesia during colonoscopy resulted in more stable haemodynamic responses and shorter recovery and discharge time. So the purpose of the study was to compare study of haemodynamic stability of propofol versus etomidate during Endoscopic Retrograde Cholangiopancreatography.Material and Methods: Patients were divided for sedation into 2 groups – etomidate and propofol. Haemodynamic response to induction agent etomidate or propofol by measuring the systolic pressure, diastolic pressure, mean arterial pressure and heart rate starting from baseline values followed by measuring the same at serial intervals during the procedure. Results were analysed in both groups Results: It was found that the average time from stoppage of sedation to the time to reach a Ramsay sedation score of lesser than 3 was higher in the patients receiving propofol. The mean time of recovery was 8.68 minutes for propofol and 6.28 min for etomidate; this was found to be statis tically significant, with a p value < 0.05. Conclusion: our study shows that etomidate as an agent for procedural sedation during ERCP caused more stable haemodynamics compared to propofol, Thus we conclude that etomidate is a good sedative agent for ERCP in ASA I – III patients.