Analgesic efficacy of intraperitoneal vs intravenous dexmedetomidine as adjuvant to levobupivacaine 0.25% in laparoscopic cholecystectomy under general Anaesthesia

Abstract

Results: VAS score was significantly lower in dexmedetomidine group D, BD from 1hr to 8hr. From 8 hr to 24 hr, VAS score in group IV dexmedetomidine was significantly less than the other groups (P=0.01). In the postoperative period, sedation scores were more in IV dexmedetomidine group as compared to other groups till 4 hrs. The requirement of rescue analgesia in IV dexmedetomidine + IP levobupivacaine was significantly less from zero hrs to 8 hrs. Conclusion: Low bolus dose of IV dexmedetomidine is more efficacious as compared to IP dexmedetomidine (0.5 µg/kg) along with IP bupivacaine in laparoscopic cholecystectomy.