Isolation of 3, 5, 7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl) chromen-4-one from the stem bark of Lonchocarpus sericeus Poir. (Papilionaceae)

Abstract

An O-methylated flavonol 3, 5, 7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl) chromen-4-one (isorhamnetin) was isolated from the dichloromethane fraction of the stem bark of Lonchocarpus sericeus Poir., (Papilionaceae), a medicinal plant widely employed in folkloric medicine in many communities in Southern Nigeria for the treatment of inflammation and pain. Its structure was established by a combination of spectroscopic techniques including FT-IR, 1HNMR, 13CNMR, 2-dimensional NMR spectroscopy, ESI-MS/MS and by direct comparison with literature values. This is the first report of the isolation of this compound from the plant L. sericeus.