Study of iron markers and their relationship with HbA1c level in type 2-DM-Bagalkot tertiary care centre

Abstract

Diabetes Mellitus (DM) is one of the most prevalent endocrine disorders in the world. It comprises a group of common metabolic disorders that share common phenotype of hyperglycemia. Impaired insulin release in Type 2DM is linked to various trace elements like iron, magnesium, chromium etc. Systemic iron overload leads to increased oxidative stress which results in abnormal glucose metabolism. The defects in insulin-producing and insulin-sensitive tissues caused by iron-dependent catalysis is via the Fenton’s reaction of reactive oxygen radical species. Present study was undertaken to assess level of serum ferritin, free iron concentration, TIBC, transferrin saturation in type 2 Diabetes mellitus patients with good and poor glycaemic control and find out correlation between serum ferritin, free iron concentrations with glycaemic control. The study was conducted between January-August 2018 at SNMC & HSK Hospital Bagalkot. It’s a case control study. Sample size included 120 subjects out of which 60 are diagnosed Type 2DM (cases) attending medicine OPD at SNMC & HSK, RC Bagalkot and 60 Healthy control appropriately matched for age and sex. The glucose parameters and serum iron, ferritin, TIBC, Transferrin saturation and Hb were high in cases compared to controls and was statistically significant. Serum iron and ferritin showed positive correlation with impaired glycaemic control. From this study it suggests that vital role of iron is metabolically deranged in diabetic patients.