Adverse perinatal outcomes at advanced maternal age: An experience from a large Indian cohort

Abstract

Background: The incidence of pregnancies at older age is on an increase internationally but there is disturbing body of evidence which implicates adverse perinatal outcomes in mothers at advanced age.Patients and Methods: The study was conducted as an ambispective cohort study at a tertiary care Medical College Hospital over a period of 4and a half years from December 2013 to May 2018 to evaluate the outcomes associated with the risk.Results: Obesity, higher socio-economic status, higher literacy and assisted conception appeared to be the statistically well associated with conception at advanced age. A statistically significant association was observed between the fetuses of older mothers developing foetal growth restriction (aRR-1.67, CI -1.37 – 1.98; P