Spectrum of histopathological lesions of prostate in a tertiary care center

Abstract

Background: Prostatic diseases like inflammation, benign prostatic hyperplasia and tumors are important causes of mortality and morbidity in males. The incidence of prostatic diseases increases with advancing age. The present study is to evaluate histomorphological spectrum of lesions in prostate and to classify prostatic carcinoma by using modified Gleason score and Prognostic grade group. Result: During the study period, 90 specimens of prostate were received in pathology department, HIMS, Hassan. Age of patients ranged from 40 years to 90 years with a mean age of 67.5 years. Prostatic cancer was most commonly seen in 7th decade. Out of 90 cases, non neoplastic 58 cases (64.4%), premalignant 7 cases (7.8%) and neoplastic 25 cases (27.8%). Benign hyperplasia of prostate (BPH) was the most common histological diagnosis (44cases) followed by prostatic adenocarcinoma (25 cases).Conclusions: The present study showed that non-neoplastic lesions of prostate were more common than neoplastic ones. Prognostic grade group should be applied for prostatic carcinoma which is simple and more accurate grade stratification than modified Gleason score.