Cytotoxicity screening of curcumin on HeLa cancer cell lines

Abstract

Phytocompounds are most extensively studied as an alternative approach in cancer therapeutics. Curcumin is one of the leading compounds from turmeric that has been most extensively studied for its promising pharmacological effects. In the present study, the cytotoxicity potential of curcumin was determined by MTT [3-(4, 5-dimethylthiazolyl-2)-2, 5- diphenyltetrazolium bromide] assay on HeLa cancer cell lines. The MTT assay was conducted at 48h incubation to determine percent cell viability. The IC50 values of curcumin was 3.36μM. The curcumin showed dose-dependent cytotoxicity on cervical epithelioid adenocarcinoma cells. The in vitro cytotoxicity potential of curcumin in terms of percent cell viability proved to be more effective on HeLa cells.