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Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages

Cancer Letters · 2020 · Vol. 474 · pp. 36–52
Dong WangXiaohui WangMahan SiJuan YangShiyue SunHaochen WuShu‐Xiang CuiXian‐Jun QuXinfeng Yu
Extracellular vesicles in diseaseMicroRNA in disease regulationImmune cells in cancerMetastasisMicrovesiclesCancer researchExosomeCXCR4PI3K/AKT/mTOR pathwayMacrophage polarizationmicroRNAPTENEpithelial–mesenchymal transition

MeSH terms

AgedAnimalsCell MovementFemaleHumansLiver NeoplasmsMacrophagesMaleMice, Inbred BALB CMice, NudeNeoplasm InvasivenessPrognosisTumor Cells, CulturedBiomarkers, TumorColorectal Neoplasms

Funding

  • National Natural Science Foundation of China
  • Natural Science Foundation of Beijing Municipality
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