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RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 FOR TREATMENT OF OPEN TIBIAL FRACTURES
Journal of Bone and Joint Surgery · 2002 · Vol. 84(12) · pp. 2123–2134
Abstract
The rhBMP-2 implant was safe and, when 1.50 mg/mL was used, significantly superior to the standard of care in reducing the frequency of secondary interventions and the overall invasiveness of the procedures, accelerating fracture and wound-healing, and reducing the infection rate in patients with an open fracture of the tibia.
Bone fractures and treatmentsOrthopedic Surgery and RehabilitationKnee injuries and reconstruction techniquesMedicineNonunionSurgeryIntramedullary rodBone healingImplantRandomized controlled trialConfidence intervalInternal medicine
MeSH terms
AdolescentAdultAgedAged, 80 and overFemaleFractures, OpenHumansMaleMiddle AgedProspective StudiesRecombinant ProteinsTibial FracturesSingle-Blind MethodTransforming Growth Factor betaBone Morphogenetic Proteins
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References
Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound.
Journal of Bone and Joint Surgery · 1994 · 954 citations
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