article Open AccessTop 1% cited
Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice
Biomedicine & Pharmacotherapy · 2019 · Vol. 122 · pp. 109772–109772
Qian Ren(Sichuan University)Fan Guo(West China Hospital of Sichuan University)Sibei Tao(West China Hospital of Sichuan University)Rongshuang Huang(West China Hospital of Sichuan University)Liang Ma✉(Sichuan University)Ping Fu(West China Hospital of Sichuan University)
Abstract
Fisetin alleviated kidney inflammation and apoptosis to protect against LPS-induced septic AKI mice via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways.
Acute Kidney Injury ResearchPhagocytosis and Immune RegulationHeme Oxygenase-1 and Carbon MonoxideFisetinMedicineAcute kidney injurySepsisPharmacologyInflammationKidneyLipopolysaccharideProinflammatory cytokineSeptic shock
MeSH terms
AnimalsFlavonoidsInflammationKidneyLipopolysaccharidesMaleMice, Inbred C57BLSignal TransductionNF-kappa BGenes, srcApoptosisSepsisMAP Kinase Signaling SystemFlavonolsMice
Funding
- National Natural Science Foundation of China
Citations
401
FWCI
17.23
field-weighted impact
References
35
Percentile
100%
vs. same field & year
Citations per year
References
Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment
Kidney International · 2019 · 1,383 citations
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