One pot synthesis of fluorinated carbamodithioato copper complexes as antifungal agents

Abstract

Novel fluorocarbamodithioa to copper (II) complexes were synthesized by one pot two step reaction protocol by the reaction of fluoroanilines with carbon disulfide followed by the addition of copper chloride, with the aim to evaluate their antifungal potential. The relative evaluation of fluoro and non-fluoro carbamodithioato copper complexes for their in vitro antifungal potential against various phytopathogenic fungi viz. Puccinia hordei, Puccinia striiformis and Bipolaris sorokiniana revealed remarkable potential of non-fluorinated complexes in comparison to fluorinated analogues. Tetraaqua phenyl carbamodithioa to copper (II) chloride (1a) inflicted the highest fungitoxicity in most of the cases.