Synergistic analgesic activity ofchloroform extract of Lawsonia inermis Linn.and Chlorophytum borivilianum Sant.

Abstract

This work has done for the determination of the synergistic analgesic activities of chloroform extracts of leaves and roots tubers of Lawsonia inermis Linn. and Chlorophytum borivilianum Sant. in mice. The chloroform extract was studied for synergistic activity by using tail immersion and hot plate methods. The study revealed that the chloroform extract of both the drugs at the dose level of 200 mg/kg body weight significantly produced analgesic activity, but combination of both the extract showed more analgesic activity as compare to Lawsonia inermis Linn and Chlorophytum borivilianum Sant. These effect, which may be due to blockade or release of endogenous substances that stimulate pain nerve endings similar to Morphine.