Studies on 3-azabicyclo [3.3.1] nonanones derivatives: A mini Review

Abstract

This review describes the recent literature surveyed regarding the synthesis of 2,4-diaryl-3-rnazabicyclo[3.3.1]nonanone (3-ABNs) and their biological activities in the last six years (2008-2014).rnThese heterocyclic compounds are obtained from the Mannich reaction of ketones, aldehydes andrnammonium acetate in polar aprotic solvents. The carbonyl group enables the functionalization of 3-ABNsrninto sulphur and nitrogen containing heterocycles such as hydrazones, oximes, hydrazide, thiazoles,rnamides and semicarbazones. The 3-ABNs heterocycles exist in chair-chair and/or boat-chairrnconformations with equatorial phenyl groups. From the surveyed literature studies the major importancernwas given to their biological activities against the different fungal and bacterial strains. The structurernactivity relationship indicated that electron withdrawing groups at the ortho and para position of the arylrnrings enhanced the antibacterial and antifungal activities.