Assessment of liver function in malaria, typhoid and dengue diseases in Peshawar, Pakistan

Abstract

Malaria, typhoid fever and dengue infections are considered as the most prevalent diseases in tropics and are primarily connected with poverty and underdevelopment with significant morbidity and mortality rates. In this study 90 patients both males and females between the age of 22 to 40, (30 malarial patients, 30 typhoid patients and 30 dengue patients) were included from Hayatabad medical complex Peshawar to assess their liver function, and 20 healthy individuals were included as placebo. Blood samples collected from these subjects were screened for malaria, typhoid and dengue infection using standard methods. Mean value of serum level of ALP (110.9±16.1), ALT (30.1±6.9), AST (42.5±7.3), TB (23.8±7.0), CB (6.4±1.8) for malaria, ALP (124±17.8), ALT (29.9±5.2), AST (26.9±3.5), TB (21.8±2.9), CB (5.3±1.6) for typhoid and ALP (121.7±16.1), ALT (270.2±58.0), AST (137.5±39.6), TB (65.1±16.6), CB (12.6±3.4) for dengue were obtained for these subjects. Comparison of ALP level in Malaria, Typhoid and Dengue infections were also assessed where typhoid showed high level of ALP i.e. 125(IU/L), High ALT, AST, TB and CB level showed by Dengue i.e. 140 (IU/L), 400 (IU/L), 60 (Umol/L), 12 (Umol/L) respectively. These finding suggested that if the Malaria, Typhoid and Dengue infections are not treated properly there will be an increase in the level of ALP, ALT, AST, TB and CB and will cause damage to the liver.