The ameliorative effect of Petroselinum crispum (parsley) on some diabetes complications

Abstract

This study is aimed to evaluate the hypolipidemic effect of parsleyaqueous extract (PAE) and its effect on heart tissue of diabetic rats. Diabetes induced by subcutaneous injection of streptozotocin (STZ). Sixty diabetic rats were equally divided into four groups: control diabetic rats, diabetic rats treated with PAE and/or gliclazide. In addition, sixty normal rats were equally divided into four control groups: control non-treated rats, normal rats treated with PAE and/or gliclazide. The experiment lasted for 45 days. STZ injection induced a significant increase in plasma total cholesterol, triglycerides, low-density lipoprotein levels and glutathione transferase activity in association with a significant decrease in plasma high-density lipoprotein, whole blood glutathione and serum homocysteine levels. Expression of caspase-3 in cardiac tissue was affected by STZ injection. In conclusion, administration of PAE significantly attenuates the hyperlipidemia, overcomes the oxidative stress and improves heart tissue of diabetic rats.