Preclinical study on cardioprotective effect of ethanolic extract of Eucalyptus globulus against doxorubicin induced cardiotoxicity

Abstract

Doxorubicin is an effective broad-spectrum anthracycline chemotherapeutic agent successfully used in the treatment of a wide range of malignancies. However, the effectiveness of this drug has become limited by the occurrence of dose related cardiotoxicity and heart failure. The aim of the present study was to investigate the potential cardioprotective effect of “Eucalyptus globulus” against doxorubicin induced cardiotoxicity in the Wister albino rats. Animals received either Doxorubicin (3 mg/kg, i.p.) every other day or combination of E. globulus (100mg/kg and 200mg/kg;p.o.) with Doxorubicin or E. globulus (200mg/kg;p.o.) extract alone for 2 weeks. Cardiotoxicity was assessed by recording changes in ECG (increased QT interval), measuring the levels of cardiac marker enzymes such as lactic acid dehydrogenase (LDH), creatinin kinase (CK-MB) at the end of treatment schedule. Treatment with E. globulus (100mg/kg and 200mg/kg) significantly (p