Morinda citrifolia (Noni) changes the expression of AdipoR2 mRNA in hepatic tissue of rats with nonalcoholic fatty liver disease (NAFLD)

Abstract

Morinda citrifolia (Noni) have different therapeutics and hepatoprotective effects, the last effect is controversial; this study evaluated the effects of Morinda citrifolia leaf extract on expression of AdipoR2 mRNA in rats with nonalcoholic fatty liver disease (NAFLD). Four groups of wistar rats were utilized: C, NAFLD-Suc, NAFLD-Suc/Mc and NAFLD/Mc. The inductor of NAFLD was sucrose at 40% in water to drink. The Rats of the NAFLD-Suc/Mc and NAFLD/Mc groups received 200 mg of extract (2 weeks). We observed difference in the body weight of rats intaking sucrose with respect to control group, during ten weeks of treatment. The NAFLD/Mc group showed decrease of liver weigth, index liver and reversion of fatty liver with respect to NAFLD-Suc group. The same way, decrease expression of the gene AdipoR2 that codes for the receptor of adiponectine, wich could be associated with the reduction of the content of triglycerides in the liver.