Phytochemical screening and antimicrobial activity of leaf, seed and central-fruit-axis crude extract of Swietenia macrophylla King

Abstract

The present study aimed to evaluate the antimicrobial activities of Swietenia macrophylla crude methanolic extract of leaf, seed and central-fruit-axis. The antimicrobial activity of the leaf, seed and central fruit-axis extract was evaluated against gram-positive, gram-negative bacteria and fungi based on the inhibition zone using well diffusion assay. The crude extracts of S. macrophylla were subjected to various phytochemical screening tests. The phytochemical tests exhibited the presences of common phytocompounds such as alkaloids, flavonoids, tannins, terpenoids, glycosides, saponins, volatile oils, amino acids and proteins as major active constituents. The SMCM seed extract had significant level of inhibitory effects on the growth of bacteria viz., Staphylococcus aureus, E. coli and fungi viz., Fusarium sp, Helminthosporium sp and Alternaria sp. The antimicrobial activity exhibited a linear relationship with extract concentrations. The seed extracts proved potential extract against fungal growth.