Evaluation of platelet augmentation activity of Carica papaya leaf aqueous extract in rats

Abstract

Carica papaya leaves have been used traditionally to treat indigestion, as a vermifuge. Carica papaya leaves have also been shown to possess anti-tumor and immunomodulatory effects. The current study aims at determining the effect of Carica papaya leaves aqueous extract in increasing the platelet count in thrombocytopenic rat model. Aqueous extract of Carica papaya leaves at concentration of 400mg/kg and 800mg/kg were given to cyclophosphamide induced thrombocytopenic rats for a period of fifteen days. Blood was withdrawn at various time intervals to determine the platelet count. Also, the clotting time was determined on the 15th day of the study by capillary method. Carica papaya leaf extract was found to increase the platelet count and also to decrease the clotting time in rats. The study aims at determining the possible effects of papaya leaves in thrombocytopenia occurring in dengue fever.