Nephroprotective activity of different extracts of Biophytum sensitivum (Linn.) DC

Abstract

The present study was undertaken to evaluate nephroprotective activity of different extracts of whole plant of Biophytum sensitivum in Wistar albino rats. Randomly selected animals were divided into five groups of six animals each. The test extracts were administered orally at a dose of 200 mg/kg. Gentamicin was administered at a dose of 40 mg/kg i.p. to the rats for 7 days. On eighth day all the animals were sacrificed and blood was collected. Elevation of urea and creatinine level in the serum was taken as the index of nephrotoxicity. Histopathological examinations of kidneys of all the groups were carried out. The findings revealed that methanol and aqueous extracts of Biophytum sensitivum possesses nephroprotective activity. The elevations of serum urea and creatinine produced by Gentamicin were considerably reduced and showed histopathological changes in the kidneys to normal. The study concluded that Biophytum sensitivum possess nephroprotective activity.