article

Inclusion Studies on oral antidiabetic drugs with α-Cyclodextrin and Hydroxypropyl α-Cyclodextrin

International journal of applied research · 2015 · Vol. 1(12) · pp. 977–983

Abstract

Pioglitazone hydrochloride and Glimepiride are antidiabetic drugs. These antidiabetic drugs are poorly soluble in water which affect bioavailability. The main objective of the study is to investigate the solubility of two drugs via complexation with α-Cyclodextrin and Hydroxypropyl α-Cyclodextrin. Inclusion complexes in liquid state were prepared for both the drugs with α-Cyclodextrin (α-CD) and Hydroxypropyl α-Cyclodextrin (HPα-CD) and characterised by UV-VIS and Fluorescence Spectroscopy. Phase solubility studies indicated the formation of 1:1 stoichiometry of inclusion complexes and solubility enhancement on complexation with α-Cyclodextrin and HP α-Cyclodextrin

Drug Solubulity and Delivery Systems Crystallization and Solubility Studies Analytical Methods in PharmaceuticalsCyclodextrinGlimepirideBioavailabilityChemistrySolubilityPioglitazoneDrugInclusion compoundUltraviolet visible spectroscopyNuclear chemistry

Citations

FWCI

0.00

field-weighted impact

References

Percentile

30%

vs. same field & year

References

Cyclodextrins as pharmaceutical solubilizers

Advanced Drug Delivery Reviews · 2007 · 1,822 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.