A comparative study of instillation of single dose prostaglandin E2 Gel 0.5mg v/s misoprostol (PG E1) 25mcg for induction of labour

Abstract

Induction of labour using prostaglandins is a common practice nowadays. This study aims to evaluate the effect of single application of intracervical PGE2 gel 0.5 mg and tablet misoprostol PGE1 per vaginally 25 mcg and evaluates maternal mortality and morbidity and outcome after application. Induction helps to decrease the rate of cesarean sections and helps in increasing the vaginal deliveries within 24 hour. This study had shown that the induction of delivery interval was less, rate of cesarean section was less, the rate of complications were higher in the misoprostol group compared to dinoprostone. This shows that the intravaginal misoprostol is a better drug of choice in ripening of the cervix during the IOL compared to Dinoprostone. The use of randomised controlled methodology is the strength of this study. Further research with stronger methodology and adequate sample size helps in generalising the study results.