Is L-arginine supplementation has beneficial role in fetal outcome in patients of pre-ecclampsia?

Abstract

Introduction: Preeclampsia is a multisystem complex disorder with an increased uterine arterial resistance due to deficiency of e-NOS, resulting in vasoconstriction. L-arginine is the substrate of nitric oxide (NO) and therefore we aimed to study the effect of its supplementation in preeclampsia patients.Materials and Methods: The study was conducted in SN Medical College, Agra and included a total of 120 women out of which 60 were included in the study group and 60 in the placebo group, from 20 weeks of gestation onwards, complicated by Pregnancy induced hypertension and Doppler parameters were done serially at 4-6 weeks interval after supplementation of L-Arginine to see for the improvement.Results: It was found that supplementation with Arginine significantly improved the fetal outcome in patients with Pre-eclampsia.Conclusion: L-Arginine proved to be an efficient intervention to improve neonatal outcomes in patients with hypertensive disorders of pregnancy.