Helicobacter pylori associated gastritis: A histopathological study of gastric mucosal biopsies

Abstract

Background: Helicobacter pylori (H. pylori) is one of the major cause of gastrointestinal diseases. It is classified as class-I carcinogen & thus Its important to study the histological changes in H. pylori gastritis. Aim: To evaluate associated histological features and prevalence of H. pylori associated gastritis by histopathological method. Methods and Material: Biopsies from 75 patients with various upper gastrointestinal symptoms were studied. Study period was from August 2016 to August 2018. Each biopsy was stained with Haematoxylin & Eosin (H&E) & Warthin Starry silver stain. The slides were examined for H. pylori & various histological features. Results: H. pylori infection was high in the fourth decade with male predominance. 47/75 (62.6%) cases were H. pylori positive. Among H. pylori positive cases neutrophilia activity, mononuclear infiltrate, atrophy & intestinal metaplasia was seen in 93.6%, 100%, 14.9% & 2.2% cases respectively. Conclusion: Histopathological evaluation is the gold standard for diagnosing H. pylori infection. Furthermore, large scale studies are required to evaluate H. pylori associated gastritis to prevent morbidity & mortality