Evaluation of effect of <em>Trema guineensis</em> extracts on serum concentrations of vitamins A, D and E during CCl<sub>4</sub> induced hepatotoxicity in rat

Abstract

The present study investigated the preventive effect of Trema guineensis on serum concentrations of vitamins A, D and E during hepatotoxicity in rat. The leaves of Trema guineensis collected from Abobo in the district of Abidjan were used for the preparation of the aqueous extract by decoction and ethanolic extract by maceration. Then, healthy adult Wistar albino rats were used for the experimentation. The animals were pretreated with the extracts at the doses of 100 and 200 mg/kg of body weight by oral route one hour before CCl4 intraperitoneal injection for seven days. The administration of CCl4 resulted in a significant decrease of vitamins A, D and E rates in the serum while the pretreatment by the extracts increased the concentrations of these vitamins. The extracts of Trema guineensis would prevent vitamins A, D and E deficiency in serum due to hepatic injury.