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A Consensus Molecular Classification of Muscle-invasive Bladder Cancer

European Urology · 2019 · Vol. 77(4) · pp. 420–433

Aurélie Kamoun✉(La Ligue Contre le Cancer)Aurélien de Reyniès(La Ligue Contre le Cancer)Yves Allory(Centre National de la Recherche Scientifique)Gottfrid Sjödahl(Lund University)A. Gordon Robertson(BC Cancer Agency)Roland Seiler(University Hospital of Bern)Katherine A. Hoadley(University of North Carolina at Chapel Hill)Clarice S. Groeneveld(Centre National de la Recherche Scientifique)Hikmat Al-Ahmadie(Memorial Sloan Kettering Cancer Center)Woonyoung Choi(Johns Hopkins University)Mauro A.A. Castro(Universidade Federal do Paraná)Jacqueline Fontugne(Centre National de la Recherche Scientifique)Pontus Eriksson(Lund University)Qianxing Mo(Moffitt Cancer Center)Jordan Kardos(University of North Carolina at Chapel Hill)Alexandre Zlotta(Mount Sinai Hospital)Arndt Hartmann(Friedrich-Alexander-Universität Erlangen-Nürnberg)Colin P. Dinney(The University of Texas MD Anderson Cancer Center)Joaquim Bellmunt(Harvard University)Thomas Powles(Queen Mary University of London)Núria Malats(BC Cancer Agency)Keith Syson Chan(Cedars-Sinai Medical Center)William Y. Kim(University of North Carolina at Chapel Hill)David J. McConkey(Johns Hopkins University)Peter C. Black(University of British Columbia)Lars Dyrskjøt(Aarhus University Hospital)Mattias Höglund(Lund University)Seth P. Lerner(Baylor College of Medicine)Francisco X. Real(Spanish National Cancer Research Centre)François Radvanyi(Centre National de la Recherche Scientifique)Mattias AineHikmat Al-Ahmadie(Memorial Sloan Kettering Cancer Center)Yves Allory(Centre National de la Recherche Scientifique)Joaquim Bellmunt(Harvard University)Isabelle Bernard-Pierrot(Laboratoire de Biologie et Modélisation de la Cellule)Peter C. Black(University of British Columbia)Mauro A.A. Castro(Universidade Federal do Paraná)Keith Syson Chan(Cedars-Sinai Medical Center)Woonyoung Choi(Johns Hopkins University)Bogdan CzerniakColin P. Dinney(The University of Texas MD Anderson Cancer Center)Lars Dyrskjøt(Aarhus University Hospital)Pontus Eriksson(Lund University)Jacqueline Fontugne(Centre National de la Recherche Scientifique)Ewan A. GibbClarice S. Groeneveld(Centre National de la Recherche Scientifique)Arndt Hartmann(Friedrich-Alexander-Universität Erlangen-Nürnberg)Katherine A. Hoadley(University of North Carolina at Chapel Hill)Mattias Höglund(Lund University)Aurélie Kamoun✉(La Ligue Contre le Cancer)Jordan Kardos(University of North Carolina at Chapel Hill)Jaegil Kim(University of North Carolina at Chapel Hill)William Y. Kim(University of North Carolina at Chapel Hill)David J. KwiatkowskiThierry Lebrét(Université de Versailles Saint-Quentin-en-Yvelines)Seth P. Lerner(Baylor College of Medicine)Fredrik LiedbergNúria Malats(BC Cancer Agency)David J. McConkey(Johns Hopkins University)Qianxing Mo(Moffitt Cancer Center)Thomas Powles(Queen Mary University of London)François Radvanyi(Centre National de la Recherche Scientifique)Francisco X. Real(Spanish National Cancer Research Centre)Aurélien de Reyniès(La Ligue Contre le Cancer)A. Gordon Robertson(BC Cancer Agency)Arlene O. Siefker‐RadtkeNanor Sirab(Hôpital René Huguenin)Roland Seiler(University Hospital of Bern)Gottfrid Sjödahl(Lund University)Ann Taber(Friedrich-Alexander-Universität Erlangen-Nürnberg)John N. WeinsteinAlexandre Zlotta(Mount Sinai Hospital)

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Abstract

Bladder cancers are heterogeneous at the molecular level, and scientists have proposed several classifications into sets of molecular classes. While these classifications may be useful to stratify patients for prognosis or response to treatment, a consensus classification would facilitate the clinical use of molecular classes. Conducted by multidisciplinary expert teams in the field, this study proposes such a consensus and provides a tool for applying the consensus classification in the clinical setting.

Bladder and Urothelial Cancer Treatments Ferroptosis and cancer prognosis Cancer, Lipids, and MetabolismMedicineBladder cancerClinical trialDiseaseBioinformaticsComputational biologyOncologyInternal medicineCancerBiology