Vaginal misoprostol alone for first trimester termination of pregnancy

Abstract

Objective: To assess the efficacy and safety of vaginal administration of a single dose of misoprostol 800 mcg alone for first trimester termination of pregnancy and to compare the efficacy and safety of the same at gestational age less than 8 weeks and 8-12 weeks.Material and Methods: This post-hoc analysis included 35 pregnant women with intrauterine pregnancies up to 12 weeks gestational age. All the patients were administered 800 mcg misoprostol by the vaginal route. Success was defined as complete abortion within 24 hours. Failures were classified into incomplete abortion and complete failure.Results: The overall success rate was 62.86% after 24 hours of administration of single dose of 800 mcg of misoprostol. Success rate at less than 8 weeks gestation was 69.23% while it was 59.09% between 8-12 weeks. Conclusion: Vaginal misoprostol alone had a success rate of 62.86% for first trimester termination of pregnancy and there was no statistically significant difference in the success rate with respect to gestational age.