Efficacy of Ondansetron and Ramosetron in controlling propofol-induced pain: A comparative study

Abstract

Background: The present study was conducted to compare efficacy of ondansetron and ramosetron in controlling propofol-induced pain. Materials & Methods: The present study was conducted on 56 patients of both genders. Patients were divided into 2 groups of 28 each. Group I received 4 mg of ondansetron and group II received 0.3 mg of ramosetron. All the pre-treatment drugs were made into 2 ml volume with normal saline. After intravenous (IV) pre-treatment of study drug, manual occlusion of venous drainage was done at mid-arm for 1 min. This was followed by administration of propofol (1%) after release of venous occlusion. Pain was assessed with a four‑point scale. Results: Out of 56 patients, group I received ondansetron and group II received ramosetron. Pain score 1 was seen in 4 in group I and 7 in group II, score 2 was seen in 8 in group I and 12 in group II, score 3 was seen in 10 in group I and 7 in group II and score 4 was seen in 6 in group I and 2 in group II. The difference was significant (P< 0.05). Conclusion: Authors found that 0.3 mg of Ramosetron is better than 4 mg of ondansetron in controlling propofol induced pain.