Assessment of clinical profile of cases of Sarcoidosis in children

Abstract

Background: Sarcoidosis affects people of all racial and ethnic groups and occurs at all ages. The present study was conducted to assess clinical profile of sarcoidosis in children. Materials & Methods: The present study was conducted on 23 children suffering from sarcoidosis of both genders. Diagnosis of sarcoidosis was based on clinical features, documentation of non-caseating granuloma from various body tissues, raised serum Angiotensin converting enzyme (ACE) levels and raised urinary calcium to creatinine ratio. In all children, clinical features and laboratory findings were recorded. Results: Out of 23, males were 11 and females were 12. Common features were fever seen in 17, uveitis in 10, splenomegaly in 7, Hepatomegaly in 8, weight loss in 4, skin rashes in 6, difficult respiration in 4, cough in 2 and seizures in 1. The difference was significant (P< 0.05). TLC count was 10500/ cumm of blood, ESR was 54, hemoglobin level was 9.2 g/dL and serum ACE was 148 U/mL. Conclusion: Sarcoidosis is rare in children. Authors found 23 cases in children. Common clinical features were fever, difficult in respiration, weight loss etc.