Screening of antibacterial properties of Garlic (Allium sativum L.) extracts against multidrug resistant diabetic foot ulcer bacteria

Abstract

Diabetes mellitus has one of the important complications of foot ulcer. Occasionally it bring into being lower extremity of toes amputation. The pus samples were carefully collected from diabetic foot ulcer and processed in the laboratory. Most of the bacteria were isolated from foot ulcer the pus sample showed multiple drug resistance. In order to keep away from repeated use of commercial antibiotic for foot ulcer, alternative methods of herbal medicine were tested in this study. The result of the present study showed that the methanolic extract of Allium sativum (Garlic) have excellent antibacterial activity against foot ulcer microflora. Highest zone of inhibition was observed on 300µg of methanolic extract of Allium sativum. The presence of active components like flavonoids, alkaloids, steroids and triterpenes in the methanol extract of A. sativum that gave excellent antibacterial activity against foot ulcer microflora.