Assessment of serum lipid profile in patients undergoing laparoscopic cholecystectomy

Abstract

Background: Cholecystectomy has long been considered as a safe procedure, while secondary effects have been overlooked where the gallbladder is a ‘controller’ operating in concert with key pathways governing metabolic homeostasis. If the gallbladder is removed, the bile in the liver will directly enter the upper part of the intestine. Hence; the present study was undertaken to assess serum lipid profile in patients undergoing laparoscopic cholecystectomy. Materials and Methods: A total of 50 gallstone patients were included. Preoperative blood samples were taken from all the patients under septic conditions two hours before surgery for assessing the preoperative lipid profile. Laparoscopic cholecystectomy was carried out in all the patients under the hands of skilled and experienced surgeons. Postoperative samples were obtained at one week postoperatively and were sent to lobotomy for assessment of postoperative lipid profile. Various serum lipid parameters that were analyzed included: Total cholesterol (TC), High-density lipoprotein cholesterol (HDL-C), and Triglycerides (TGs). All the results were recorded in Microsoft excel sheet and were analyzed by SPSS software. Results: Mean TC levels preoperatively and postoperatively were 165.5 mg% and 152.8 mg%. Mean HDL-C levels preoperatively and postoperatively were 45.1 mg% and 42.8 mg%. Mean TG levels preoperatively and postoperatively were 190.8 mg% and 210.8 mg%. Significant results were obtained while comparing the mean TC levels and mean TGs levels preoperatively and postoperatively. Conclusion: Significant alterations in the serum lipid profile occurs in patients undergoing laparoscopic cholecystectomy.