Anti-hemostatic protease from Jatropha curcas latex with fibrinogen lytic activity

Abstract

The Jatropha curcas plant has been used since ancient time to treat open wounds, haemorrhage, to stop blood loss and to enhance wound healing process in folklore/tribal medicine by the people of tropical, subtropical and semi-arid countries. Discovery of new therapeutic molecule(s) is necessary to treat the thrombotic and other disorders in coagulation. There is a need to evaluate and isolate active molecules with medicinal property. This study is conducted to evaluate and characterize the Jatropha curcas plant latex for its fibrinogen lytic, collagenolytic and its action on blood coagulation cascade to substantiate the use of this plant latex as antithrombotic medicine.