Association of serum hCG level with miscarriage in early pregnancy

Abstract

The aim and objective of the study was the measurement of hCG level in asymptomatic pregnant women and to determine the efficacy of hCG in preventing miscarriage in asymptomatic pregnant women. It was descriptive type longitudinal study including 178 asymptomatic pregnant women with a gestation age of 6 to 16weeks attending routine antenatal booking visit in the Department of Obstetrics and Gynaecology, S.M.S. Medical College and Attached Hospitals, Jaipur, India. Participants presented from June 2017 to November 2018. After initial clinical examination of every participants a single blood sample was taken for the measurement of serum hCG. Serum hCG measurement was performed by chemiluminescent method by using the Siemens Immulite 2000 and result were expressed as mIU/ml. Pregnancy outcome was recorded prospectively. Data were expressed in mean±SD. The median level for hCG was 87351.00 mIU/ml (range 12836.00 - 269800.00). The mean level of serum hCG in women without miscarriage (N=165) 97137.53±53745.46 mIU/ml and women with miscarriage (N=13) 48725.31±21933.20 mIU/ml (P<0.002). Further distribution of women with miscarriage (N=13) according to time to diagnosis (days) into three group [<10days (N=3) 44016.67±28495.53, 10-20days (N=8)45903.25±21413.01,>20days (N=2) 67076.50±11636.86] (P value 0.473). Therefore, in our study serum levels of hCG have been suggested as a biomarker for miscarriage and for early pregnancy viability.