Thromboprophylaxis with single dose versus seven dose enoxaparin in intermediate risk postpartum women: A single blinded randomized control study

Abstract

Venous thromboembolism is a life threatening condition, commonly affecting pregnant and puerperal women and requires thromboprophylaxis for prevention. There are no clear guidelines regarding duration of thromboprophylaxis in intermediate risk postpartum women. We have conducted a randomized control study to compare the efficacy of a single dose thromboprophylaxis with seven days regimen in a tertiary care hospital over one year. We selected 1280 intermediate risk postpartum patients and randomised into two groups. The study group was given a single dose and the control group received seven doses of Enoxaparin. Incidence of thromboembolism in both groups were analysed. Both groups were comparable in terms of risk factors. Deep vein thrombosis developed in 0.31% of the study population and 0.16% of the control group, showing a similar outcome. We concluded that single dose regime can be used as effectively as seven dose to reduce the occurrence of thromboembolism and its related morbidity and mortality in postpartum women.