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A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential

BMC Cancer · 2019 · Vol. 19(1) · pp. 581–581

Emily Gobin✉(Augusta University)Kayla Bagwell(Augusta University)John L. Wagner(Augusta University)David Mysona(Augusta University)Sharmila Sandirasegarane(Augusta University)Nathan D. Smith(Augusta University)Shan Bai(Augusta University)Ashok Sharma(Augusta University)Robert J. Schleifer(Augusta University)Jin‐Xiong She(Augusta University)

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Abstract

Most MMPs have consistently increased gene expression across cancers, while several MMPs have consistently decreased expression in several cancer types. Many MMPs have diagnostic value individually or in combination, while the prognostic value of MMPs is restricted to one subtype of kidney cancer.

Protease and Inhibitor Mechanisms Bone and Dental Protein Studies Peptidase Inhibition and AnalysisMMP1MMP3MMP2Matrix metalloproteinaseCancerSurgical oncologyCancer researchMMP9MetastasisMedicine

MeSH terms

Carcinoma, Renal CellHumansKidney NeoplasmsNeoplasmsPrognosisRNA, MessengerBiomarkers, TumorUp-RegulationGene Expression Regulation, NeoplasticMatrix Metalloproteinase 9Matrix MetalloproteinasesMicroarray AnalysisMatrix Metalloproteinase 11Matrix Metalloproteinase 13Transcriptome