articleTop 10% cited
A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9′,2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-inflammatory agents
Bioorganic & Medicinal Chemistry Letters · 2008 · Vol. 18(16) · pp. 4538–4543
Hend N. Hafez(National Research Centre)Mohamed I. Hegab(National Research Centre)I. S. Ahmed Farag(National Research Centre)Abdel-Rahman B.A. El-Gazzar✉(National Research Centre)
Synthesis and biological activityBioactive Compounds and Antitumor AgentsSynthesis of heterocyclic compoundsChemistryXantheneXanthoneNitrileThiadiazolesIbuprofenAnalgesicRegioselectivityStereochemistryCycloaddition
MeSH terms
AnalgesicsAnimalsChemistry, PharmaceuticalFemaleMaleModels, ChemicalMolecular ConformationMagnetic Resonance SpectroscopySpiro CompoundsThiadiazolesThiazolesThioxanthenesDrug DesignRats, Sprague-DawleyCrystallography, X-Ray
Citations
246
FWCI
3.09
field-weighted impact
References
25
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91%
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Cited by
Silica sulfuric acid catalyzed an efficient and green protocol for the synthesis of 2-amino-5-aryl-1, 3, 4-thiadiazole
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References
Comprehensive organic chemistry
Tetrahedron Letters · 1978 · 2,797 citations
Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
Experimental Biology and Medicine · 1962 · 5,635 citations
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