Anti-hypothyroid potential of Bauhinia variegate and Commiphora mukul extracts in albino wistar rats: A histopathological investigation

Abstract

The present strategies used for the management of hypothyroid conditions are associated with various side effects. To overcome this, ethanolic extracts of Bauhinia variegate and Commiphora mukul gum resin were evaluated for their effect in the regulation of hypothyroidism in Albino wistar rat model. The study initiated with the preparation of ethanolic extract of non-woody aerial parts of Bauhinia variegate and Commiphora mukul gum resin. The phytochemical screening was followed via acute oral toxicity studies. To evaluate the effect of extracts, Methimazole-induced hypothyroid Albino wistar rats were used followed via histopathological examination. Animals were treated with individual and combined dose (100, 200 and 400 mg/kg) of plants extracts. As per the acute toxicity studies, 400mg/kg body weight was chosen as the maximum dose for the animal studies. Histopathology studies showed that a combined extract dose of Bauhinia variegate and Commiphora mukul gum resin showed more beneficial effects than the individual plant extract doses.