Role of serum CA125 levels in predicting the outcome of threatened abortion

Abstract

The purpose of the present investigation was to evaluate the prognostic role of serum CA125 in patients of threatened abortion and to find the cut off levels of maternal serum CA-125 in foreseeing the pregnancy results in patients with threatened abortion. 60 patients complaining of vaginal bleeding or spotting in first trimester were recruited and their outcome was evaluated at 20 weeks. The study was done on the women aged 20-40 yrs with gestation age between 7 to 14 weeks. The study revealed that CA 125 levels estimation is an appropriate tool in predicting outcome of threatened abortions. The ROC graphs gives the cut off level of 60 IU/ml in predicting the risk of abortion, with the sensitivity of 72%, specificity of 88.8%, PPV of 72%, NPV of 88% and accuracy of 89.83%. Thus making CA 125 clinically important in predicting the outcome of patients with threatened abortion at an early stage of gestation.