Adverse obstetrical and perinatal outcome with increasing levels of lacate dehydrogenase enzymes in patients of preeclampsia and eclampsia

Abstract

Objectives: To correlate the severity of the disease, maternal and perinatal outcome with lactate dehydrogenase (LDH) levels in serum in patients of preeclampsia and eclampsia. Methods: It was prospective observational study done in Obstetrics and Gynaecology department of Government Medical College and Rajindra Hospital, Patiala. Study was done from January 2017 to December 2017. 200 Pregnant patients were included in the study. There were 50 patient of mild pre eclampsia, 50 patients of severe pre eclampsia, 50 patients of eclampsia and 50 normotensive patients were taken as controls. Results: LDH levels were significantly elevated in women with pre eclampsia and eclampsia. As the severity of disease increased, LDH levels increased. Higher LDH levels had significant Correlation with high blood pressure as well as poor maternal and perinatal outcome. Conclusions: High serum LDH levels correlate well with severity of disease and poor Maternal and foetal outcome in patients of preeclampsia and eclampsia.