Predictive significance of serum Cystatin-C and serum lipids in preeclampsia

Abstract

Introduction: Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. Moreover there is evidence of increased oxidative stress due to endothelial dysfunction in pre-eclampsia and increase in the oxidative stress is associated with abnormal lipid profile. Objective: This study was aimed to evaluate the diagnostic efficiency of cystatin-C as an early marker of renal function and correlate with lipid profile in preeclampsia.Materials and methods: The study was conducted on 80 pregnant women in third trimester who attended HMCH (O&G Department), Rourkela. They were divided in two groups A & B. Group A consisted of 40 normal pregnant women and Group B consisted of 40 pregnant women with preeclampsia. Lipid profile was done by auto analyzer using recommended kit and cystatin-C by immunoturbidrimetric method. Results: Serum total cholesterol, LDL, HDL showed no significant change in the two groups (p>0.05). However serum triglycerides levels were found significantly higher in preeclampsia patients when compared to normotensive pregnant subjects. Similarly serum cystatin-C was significantly higher in group B (p