Serum ferritin changes on administration of intravenous iron in iron deficiency anemia in pregnancy

Abstract

The objective of this study was to see the changes in the serum ferritin levels on administration of intravenous iron sucrose in iron deficiency anemia during 14 to 34 weeks of pregnancy. A clinical trial was performed involving 56 patients attending the antenatal clinic at Shri B M Patil Medical College Hospital, Bijapur from October 2011 to August 2012, with serum ferritin of < 15 ng/ml and hemoglobin levels between 70-110g/L. Iron sucrose was administered as 200 mg in 100 ml 0.9% sodium chloride per day. The primary outcome measures, serum ferritin and haemoglobin levels were measured after 4 weeks. The change in serum ferritin was 112.17 ± 98.15 ng / ml (Mean ±SD) which was significantly higher with T value 5.11 and P value being < 0.0001. 48% of patients showed increase in ferritin level between 51 to 100 ng/ml. Serum ferritin levels increase with intravenous iron sucrose administration thus making it effective in increasing maternal iron stores along with correction of anemia.