Evaluation of hypoglycemic and antioxidant activities of ‘Koubru Yai’ (Stephania rotunda Engl.): An important medicinal plant used in traditional medicine of Manipur

Abstract

The traditional practices documented during plant survey conducted in the state of Manipur region revealed the use of tuber of Stephania rotunda (SR) for treatment of diabetes by the local communities. The present study was aimed to evaluate hypoglycemic and antioxidant activity of ethanol and water extracts of SR tuber. Water and alcoholic extract of SR tuber were compared for total phenolic, flavonoids, antioxidant and α-amylase inhibition activity. The alcoholic extract of Stephania rotunda having high concentration of total Phenols and Flavonoid showed significant α-amylase inhibition activity (IC50 = 78.06µg/mL) and also antioxidant activities (DPPH) as compared to water extract. The present study provides the evidence that the use of Stephania rotunda tubers help in maintaining blood sugar level by the local communities of Manipur. Further, this study will also provide leads for future drug development programme for amelioration of diabetes.