Cumulative toxic effect and identification of non-toxic dose of Allium sativum (Garlic) and Withania somnifera (Ashwagantha) in Native chicken

Abstract

The present study was conducted to explore the cumulative toxic effects and the non-toxic doses of Allium sativum and Withania somnifera individually and in combination in native chicken. Eighty native chicks divided into ten groups and they were supplemented with A.sativum bulb powder @ 0.5%, 1.5% and 3% and W.somnifera root powder @ 1%, 3% and 5% and their selected three combination doses in feed from 15th day to four months of age. The cumulative dose toxic effects of herbs on vital organs were assessed by estimation of liver function enzymes (SGOT and SGPT) and kidney function parameters (uric acid and creatinine) in UV double beam Spectrophotometer. The data were analysed in one way ANOVA using SPSS software. The significant (P< 0.05) differences with was not observed in liver function enzymes value of all groups whereas higher serum uric acid (5.20 ± 0.10 mg/dL) than control group (3.24± 0.05 mg/dL) recorded in A.sativum - 3% group. On conclusion, except 3% A. sativum dose, other dose of both herbs can be used safely without affecting native chicken performance.