Evaluation of antihypertensive activity of Sumbul-ut-Tib (Nardostachys jatamansi) in adrenaline induced dog’s blood pressure

Abstract

Background: Sumbul-ut-Tib has been used in Unani System of medicine since the time of Avicenna. He has described Jatamansi as one of the important cardiac drug in his book “Advia Qalbia”. The aim of this study was to determine the antihypertensive activity of Nardostachys jatamansi in dog’s blood pressure which is induced by adrenaline. Materials and Methods: Antihypertensive activity of ethanolic extract of Sumbul-ut-Tib at the doses of 10 mg/kg. b.wt, 20 mg/kg b.wt. and 25 mg/kg b.wt. against adrenaline at the dose of 1 mcg/kg b.wt. in dogs. Results: The test drug produced fall in B.P. was noted, fall in B.P. was same in doses of 10 mg/kg. b.wt, 20 mg/kg. b.wt, while with the dose of 25 mg/kg. b.wt. more fall in B.P. was noted i.e. 160 mm of Hg to 130 mm of Hg. Conclusion: This result suggests that the jatamansi revealed hypotensive activity against adrenaline induced hypertension.