article Open AccessTop 1% cited
Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling
BMC Cancer · 2019 · Vol. 19(1) · pp. 137–137
Cassandra Ringuette Goulet✉(The Society of Gynecologic Oncology of Canada)Audrey Champagne(The Society of Gynecologic Oncology of Canada)Geneviève Bernard(Université Laval)Dominique Vandal(Université Laval)Stéphane Chabaud(Université Laval)Frédéric Pouliot(Centre hospitalier universitaire de Québec)Stéphane Bolduc(Université Laval)
Abstract
We conclude that CAFs promote aggressive phenotypes of non-invasive bladder cancer cells through an EMT induced by the secretion of IL-6.
Bladder and Urothelial Cancer TreatmentsCancer Cells and MetastasisUrinary and Genital Oncology StudiesEpithelial–mesenchymal transitionVimentinCancer-Associated FibroblastsCancer researchStromal cellBladder cancerCancer cellParacrine signallingExosomeCancer
MeSH terms
Cancer-Associated FibroblastsUrinary Bladder NeoplasmsCell MovementCell SurvivalHumansPrognosisSignal TransductionBiomarkersInterleukin-6MitomycinParacrine CommunicationCell Line, TumorCell ProliferationSTAT3 Transcription FactorExosomes
Funding
- Canadian Urological Association
- Bladder Cancer Canada
- Ferring
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- Institute of Musculoskeletal Health and Arthritis
Citations
323
FWCI
31.81
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References
48
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100%
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