article Open AccessTop 1% cited
Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort
European Journal of Cancer · 2019 · Vol. 109 · pp. 36–50
Sigbjørn Smeland✉(Oslo University Hospital)Stefan Bielack(Olgahospital)Jeremy Whelan(University College Hospital)Mark L. Bernstein(Dalhousie University)Pancras C.W. Hogendoorn(Leiden University Medical Center)Mark Krailo(Arcadia)Richard Görlick(The University of Texas MD Anderson Cancer Center)Katherine A. Janeway(Dana-Farber Cancer Institute)Fiona C. Ingleby(MRC Clinical Trials Unit at UCL)Jakob AnningaImre Antal(Semmelweis University)Carola Arndt(Mayo Clinic)Ken Brown(University of British Columbia)Trude Butterfaß‐Bahloul(University Hospital Münster)Gabriele Calaminus(University Hospital Bonn)Michael Capra(Children's Health Ireland at Crumlin)Catharina Dhooge(Ghent University Hospital)Mikael Eriksson(Lund University)Adrienne M. Flanagan(Royal National Orthopaedic Hospital)Godehard Friedel(Klinik Schillerhöhe)Mark C. Gebhardt(Dana-Farber Cancer Institute)Hans Gelderblom(Leiden University Medical Center)Robert E. Goldsby(University of California San Francisco Medical Center)Holcombe E. Grier(Dana-Farber Cancer Institute)R. J. Grimer(Royal Orthopaedic Hospital)Douglas S. Hawkins(University of Washington)Stefanie Hecker‐Nolting(Olgahospital)Kirsten Sundby Hall(Oslo University Hospital)Michael S. Isakoff(Connecticut Children's Medical Center)Gordana Jovic(MRC Clinical Trials Unit at UCL)Thomas Kühne(University Hospital of Basel)Leo Kager(St Anna Children's Hospital)Thekla von Kalle(Olgahospital)Edita Kabíčková(University Hospital in Motol)Susanna Lang(Medical University of Vienna)Ching C. Lau(Baylor College of Medicine)Patrick J. Leavey(Children's Medical Center)Stephen L. Lessnick(Nationwide Children's Hospital)Leo Mascarenhas(University of Southern California)Regine Mayer‐Steinacker(University Hospital Ulm)Paul A. Meyers(Memorial Sloan Kettering Cancer Center)Raj Nagarajan(Cincinnati Children's Hospital Medical Center)R. Lor Randall(Primary Children's Hospital)Peter Reichardt(Helios Kliniken)Marleen RenardCatherine Rechnitzer(University of Copenhagen)Cindy L. Schwartz(The University of Texas MD Anderson Cancer Center)Sandra J. Strauss(University College Hospital)Lisa A. Teot(Boston Children's Hospital)Beate Timmermann(Essen University Hospital)Matthew R. Sydes✉(MRC Clinical Trials Unit at UCL)Neyssa Marina(Five Prime Therapeutics (United States))
Abstract
In conclusion, data from >2000 patients registered to EURAMOS-1 demonstrated survival rates in concordance with institution- or group-level osteosarcoma trials. Further efforts are required to drive improvements for patients who can be identified to be at higher risk of adverse outcome. This trial reaffirms known prognostic factors, and owing to the large numbers of patients registered, it sheds light on some additional factors to consider.
Sarcoma Diagnosis and TreatmentCardiac tumors and thrombiVascular Tumors and AngiosarcomasOsteosarcomaMedicineCohortOverall survivalOncologyInternal medicinePathology
MeSH terms
AdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsBone NeoplasmsChildCisplatinDoxorubicinFemaleFollow-Up StudiesHumansMaleMethotrexateNeoplasm MetastasisPrognosisOsteosarcoma
Funding
- Amgen
- Eli Lilly and Company
- Pfizer
- Bayer
- Novartis
- Takeda Pharmaceuticals North America
- European Science Foundation
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe
- AstraZeneca Schweiz
- Medical Research Council
Citations
709
FWCI
52.31
field-weighted impact
References
34
Percentile
100%
vs. same field & year
Citations per year
References
Osteosarcoma incidence and survival rates from 1973 to 2004
Cancer · 2009 · 2,142 citations
Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols
Journal of Clinical Oncology · 2002 · 1,882 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.