Herbal biomarkers in angiogenesis

Abstract

Angiogenesis is physiological process through which new blood vessels are form from pre-existing blood vessels. It is a normal and vital process in growth and development as well as wound healing and in formation of granulation tissue. It is also a fundamental step in transition of tumors from benign state to Malignant. Solid cancers cannot grow beyond a limited size without an adequate blood supply. There are many factors cause angiogenesis such as VEGF-A (Vascular endothelial growth factor), FGF-2 (Fibroblast growth factor), Angiopoietin 1 & 2, PDGF (platelet derived growth factor). It cannot grow beyond a certain size or spread without a blood supply. Hence, there are many drugs developed called Angiogenesis Inhibitors such as Bevacizumab, cetuximab etc. The plant sources are matter of great interest in recent times. Under this, extraction of plants such as Curcuma longa, Tinospora cordifolia, Azadirachta indica, etc.