Immunohistochemical diagnosis of metastatic transmissible venereal tumor in dogs

Abstract

Transmissible venereal tumor (TVT) is a well-documented transplantable tumor in dogs with no breed or sex predilection and a low metastatic rate. A 9 year female mongrel dog was presented for necropsy. Gross examination revealed roughly oval, hard, greyish white mass on right abdominal subcutis and multiple varying sized(2-14 mm) white nodules on lung lobes. Cytological and histological features were consistent with TVT. By immune histo chemical staining, the neoplastic cells were positive for vimentin and negative for S100, cytokeratin, CD3 and CD79a.